Industry Author summary Bacteriophage (phage) T4 belongs to myoviridae, a widely distributed family of viruses on Earth.
Industry Morphogenesis of the T4 tail and tail fibers Petr G Leiman, Fumio Arisaka, Mark J van Raaij, Victor A Kostyuchenko, Anastasia A
Industry Pigtail, also known as pigtail, has only one end with a connector, and the other end is a
Industry Viral fibrous protein part of the virion fiber, which is a thin long rod like structure, unique or multiple, appended to the tail of
Industry Bacteriophage infection, a pivotal process in microbiology, initiates with the phage''s tail
Industry At the first step of phage infection, the receptor-binding proteins (RBPs) such as tail fibers are responsible for
Industry This study revealed the high-resolution cryo-electron microscopy (cryo-EM) structures of the
Industry Tail fiber proteins can also be used as biosensing molecules to detect particular bacterial pathogens. Studying tail
Industry The crystal structure of a complex between the tail fibre and tail fibre assembly (Tfa) protein of Escherichia coli phage
Industry Abstract Normal particles of bacteriophage T4 have six long tail fibers attached to a hexagonal baseplate. T4 particles
Industry The collar and whiskers of bacteriophage T4 extend outward from the top of the tail and play a role in regulating
Industry Bacteriophages use receptor-binding proteins (RBPs) to adhere to bacterial hosts. Understanding the structure of
Industry Here, we present the structure of DT57C determined by cryo-EM, and an atomic model of the virus, which was further
Industry While this manuscript only demonstrates our assay''s ability to characterize adsorptive capabilities of phage tail fibers,
Industry Central to its infectivity is the tail fiber protein, gp17, which mediates the initial, critical step of host recognition and attachment. This
Industry Because ORF46 and ORF47 are essential for tail formation, as is the TMP (52), we propose that these three proteins form a tail
Industry Technological advances in cryo-EM in recent years have given rise to detailed atomic structures of bacteriophage tail
Industry The tail comprises six fibers made of gp17 trimers, 2 nm in diameter and 32 nm in length. May attach to host lipopolysaccharides
Industry The complicated nature of fiber structures necessitates the participation of intra- or intermolecular chaperones for their
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Industry Their singular structures, such as spikes or fibers are of special interest given their potential use in a wide range of
Industry Organization of the bacteriophage T4 long tail fiber. (A) A structural model of bacteriophage T4 virion showing the
Industry By fusing the bare fibers in the optical cable with the tail fiber, a seamless connection is established. The tail fiber has
Industry The exact mechanisms of how the tail fiber interacts with the receptor at the molecular/atomic level are critical for engineering
Industry Structural analysis enabled us to propose the assembly mechanism of phage tail fibers, in which the chaperone first
Industry Why are tail fibers important to a virus? The tailed phage T4 encodes a specialized device for this purpose, the long tail
Industry Here, we introduce RBPseg, a method that combines monomeric ESMFold predictions with a structural-based domain
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